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Using skin cells from human volunteers, researchers at the University of Pittsburgh School of Medicine have created fully functional mini livers, which they then transplanted into rats. In this proof-of-concept experiment, the lab-made organs survived for four days inside their animal hosts. These r...

Diagnosing liver damage earlier could help to prevent liver failure in many patients. About 25 percent of the U.S. population suffers from fatty liver disease, a condition that can lead to fibrosis of the liver and, eventually, liver failure. Currently, there is no easy way to diagnose either fatty ...

Coffee drinkers have reduced risks of chronic liver disease and death, with ground coffee offering the greatest benefit. Even decaf and instant coffee helped. Drinking coffee that is caffeinated (ground or instant) or decaffeinated is associated with a reduced risk of developing chronic liver diseas...

Study in mice, human blood samples, suggests HDL from the intestine may prevent liver inflammation. The body’s so-called good cholesterol maybe even better than we realize. New research from Washington University School of Medicine in St. Louis suggests that one type of high-density lipoprotei...

Researchers found that fatty liver disease causes severe nerve degeneration in the liver. With the application of a novel three-dimensional imaging technology, researchers at Karolinska Institutet in Sweden have discovered that one portion of the autonomic nervous system in the liver undergoes sever...

World Trade Center responders with the greatest exposure to toxic dust have a higher likelihood of liver disease. Mount Sinai researchers have found evidence for the first time that World Trade Center responders had a higher likelihood of developing liver disease if they arrived at the site right af...

May Also Explain Liver Fat Differences Among Men & Women A chemical modification that occurs in some RNA molecules as they carry genetic instructions from DNA to cells’ protein-making machinery may offer protection against non-alcoholic fatty liver, a condition that results from a build-up...

Dresden and Cambridge researchers identify cell type that regulates liver regeneration with touch. From the time of Aristotle, it has been known that the human liver has the greatest regenerative capacity of any organ in the body, being able to regrow even from a 70% amputation, which has enabled li...

Peripherally Produced Amyloid Causes Neurodegeneration Amyloid protein made in the liver can cause neurodegeneration in the brain, according to a new study in the open-access journal PLOS Biology, by John Mamo of Curtin University in Bentley, Australia, and colleagues. Since the protein is thou...

USC researchers show SAB-targeting therapy may reverse fatty liver disease. About 80 million Americans have fatty liver disease unrelated to alcohol abuse. Nonalcoholic fatty liver disease is associated with obesity and diabetes, and can lead to more severe liver damage such as nonalcoholic steatohe...

Exercise helps counteract fatty liver by improving the liver’s mitochondrial adaptation to excess energy intake, regulating enzymes involved in glucose and lipid metabolism, and reducing fat accumulation. This leads to improved glucose regulation and less metabolic stress, demonstrating that p...

In a new study, researchers at Karolinska Institutet have identified the presence of a specific connection between a protein and an lncRNA molecule in liver cancer. By increasing the presence of the lncRNA molecule, the fat depots of the tumor cell decrease, which causes the division of tumor c...

Women with long or irregular periods are at a higher risk of NAFLD, according to a new study. The risk is independent of obesity, highlighting the need for lifestyle changes to reduce potential health impacts. Women with long or irregular periods are known to have a higher risk of type 2 diabetes an...

Mice fed high-fat diet and supplement rich in calcium, magnesium didn’t develop liver cancer. A preclinical study adds to the growing body of evidence suggesting a multi-mineral dietary supplement called Aquamin might be a simple and effective method to prevent the long-term health effects of non-al...

In laboratory experiments, sweeteners impaired protein that rids the body of toxins and processes drugs. Results from a new study suggest that two sugar substitutes disrupt the function of a protein that plays a vital role in liver detoxification and the metabolism of certain drugs. These sugar subs...

Salk scientists improve liver regeneration in mice, which could lead to new treatments for liver disease. Mammals can’t typically regenerate organs as efficiently as other vertebrates, such as fish and lizards. Now, Salk scientists have found a way to partially reset liver cells to more youthful sta...

Using cryo-electron microscopy, researchers revealed NTCP’s structure and its role in viral binding, offering hope for new antiviral treatments. Though it is an essential gateway to the liver, NTCP had not been well described before now. Na+-taurocholate co-transporting polypeptide (NTCP) is a prote...