🦞🌯 Lobster Roll

Findings show people with long COVID-19 respond differently to COVID-19 vaccines. A new study by investigators from the Smidt Heart Institute at Cedars-Sinai suggests long COVID-19 might be caused by a dysfunction of the immune system. The study, published in the journal BMC Infectious Diseases, fou...

Researchers have found that three different HIV antibodies targeting the fusion peptide can protect monkeys from simian-HIV, offering promising insights for the development of an HIV vaccine. Three different HIV antibodies each independently protected monkeys from acquiring simian-HIV (SHIV) in a pl...

Tel Aviv University researchers found antibodies that neutralize all COVID-19 variants, potentially replacing the need for repeated boosters. Tel Aviv University scientists have isolated two antibodies that neutralize all known strains of COVID-19 – including Omicron – with up to 95% efficiency. The...

While both protect from severe disease, inactivated SARS-CoV-2 and spike mRNA COVID-19 vaccines trigger different T-cell responses. Although the total magnitude of the T-cell responses induced by mRNA and inactivated SARS-CoV-2 vaccines are comparable, the similarity ends there. This is according to...

Babies born via vaginal delivery showed enhanced vaccine responses due to beneficial gut bacteria. Breastfeeding further amplified this effect, offering insights into tailoring future vaccination strategies. A new study suggests that the way a baby is delivered may impact their immune system’s...

Sufficiently Different Vaccine Antigens Can Sideline Original Antigenic Sin, Enhancing Immunity Against New Viral Strains According to the theory of original antigenic sin (OAS), our immune systems react most strongly to the viral strains we encountered in our childhoods. This first encounter with a...

Results from a Scripps Research and UNC team pave the way for a vaccine and therapeutic antibodies that could be stockpiled to fight future coronavirus pandemics. A team of scientists from Scripps Research and the University of North Carolina (UNC) has found antibodies in the blood of certain COVID-...

By comparing the structures of protein complexes from different lineages of the dangerous Lassa virus, a Scripps Research team identified new antibodies and vaccine targets. Every year, hundreds of thousands of people in West Africa become infected with Lassa virus, which can cause Lassa fever and l...

Oral COVID-19 vaccines show promise, enhancing immunity with fewer side effects. According to a recent paper in Biology Methods and Protocols, published by Oxford University Press, researchers studying SARS-CoV-2 may have developed new methods to administer vaccines orally, which would be both ...

COVID-19 vaccine discovery could shape clinical practices globally. New research reveals as much as a four-fold increase in immune response when people alternate from one arm to the other when given a multi-dose vaccine. The laboratory study led by researchers at Oregon Health & Science Universi...

Research conducted during Germany’s COVID-19 vaccination effort shows that getting both vaccine doses in the same arm could enhance the immune response, offering insights into optimizing vaccination strategies. The question seems so banal, so trivial that nobody before has thought to ask it, s...

Researchers at Trinity College Dublin have achieved a significant breakthrough that could lead to the development of innovative immune therapies for cancer. They found that a vaccine adjuvant or “booster,” known as C100, when injected directly into tumors in an animal model, promotes pot...

New research has shown that the dangerous PF4 antibodies involved in vaccine-induced thrombosis (VITT) and similar disorders from common cold infections share identical molecular structures, highlighting implications for future vaccine development and disease management. New research conducted by Fl...

Results from NIH-funded animal models will inform the development of vaccines for humans. Using advanced immunological techniques, researchers have effectively activated the immune systems of animals to produce rare precursor B cells that can generate a type of HIV broadly neutralizing antibodies (b...

A UCSF study suggests that side effects like headaches and chills from COVID-19 vaccines indicate a robust immune response; however, uptake of the vaccine remains low in the U.S. despite ongoing fatalities. According to a UCSF-led study, symptoms such as headaches, chills, and fatigue could indicate...

A study led by The University of Texas at Austin has identified SC27, an antibody capable of neutralizing all known variants of the COVID-19 virus, opening prospects for universal vaccine development and improved treatments amid ongoing viral evolution. Researchers have identified an antibody capabl...

Repeated mRNA vaccinations boost mucosal antibodies, improving defense against COVID-19. This may help enhance protection against new variants. During the COVID-19 pandemic, many people received multiple doses of mRNA vaccines. Recent research from the VIB-UGent Center for Inflammation Research, Ghe...

Scientists discovered that repetitive HIV vaccinations can lead the body to produce antibodies targeting the immune complexes already bound to the virus — knowledge that could lead to better vaccines. In a groundbreaking study, Scripps Research scientists uncovered a new antibody response in HIV vac...

Stanford scientists discovered that a harmless skin bacterium triggers a powerful immune response. By tweaking a bacterial protein, they turned it into a living vaccine, training the immune system to fight diseases like tetanus and diphtheria. Mice given this bioengineered bacterium developed strong...

Researchers have identified antibodies that could lead to a broadly protective norovirus vaccine and new treatment options. Scientists at The University of Texas at Austin, in partnership with researchers from the University of North Carolina at Chapel Hill and the National Institutes of Health, hav...

A Japanese study has found that one group of people lose vaccine protection more quickly than others, even though they begin with higher antibody levels. Two healthcare workers receive COVID-19 vaccines on the same day. Both develop strong antibody responses at first, but six months later, one remai...

We recently added [approximate percentiles to Elasticsearch](http://www.elasticsearch.org/blog/averages-can-dangerous-use-percentile/) using T-Digest, but I thought the original paper would be more interesting to the Lobsters crowd than the implementation in ES. It's a very cool algorithm, and we...