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A key protein, LRG1, was identified as the early cause of diabetic eye damage, and blocking it may stop the disease before blindness occurs. A research team led by scientists at UCL has identified a crucial protein involved in triggering diabetic retinopathy, a condition in which high blood sugar ha...

A study reveals that the liver acts as a bidirectional hub, exchanging gut-microbiome-derived metabolic products with the heart. A research team supported by FAPESP and working at Harvard University in the United States has identified a collection of metabolites that move from the intestine to the l...

An international group of scientists led by Professor Marc-Emmanuel Dumas at Imperial College London & CNRS, working with Prof. Patrice Cani (Imperial & University of Louvain, UCLouvain), Dr. Dominique Gauguier (Imperial & INSERM, Paris) and Prof. Peter Liu (University of Ottawa Heart In...

Diabetes drugs may be doing more than managing blood sugar, they could also shape cancer biology in unexpected ways. New research is taking a closer look at how diabetes drugs may relate to cancer, with an emphasis on effects that go beyond lowering blood sugar or supporting weight control. Although...

Researchers have uncovered molecular clues linking diabetes to heart disease. Researchers at the University of Sydney have uncovered new evidence showing how type 2 diabetes directly changes the heart, affecting both its physical structure and the way it generates energy. The findings help explain w...

A little-known gene turns out to be vital for insulin production in the earliest stages of life. Recent advances in DNA sequencing, combined with new stem cell research approaches, have allowed an international group of scientists to identify a previously unrecognized form of diabetes that appears i...

A new study suggests that one of the most common diabetes treatments may speed type 2 diabetes progression by causing insulin-producing cells to lose their functional identity. Sulphonylureas have been used to treat type 2 diabetes since the early 1950s and remain among the most frequently prescribe...

A new study reveals that roasted coffee contains previously unknown compounds capable of inhibiting a key enzyme linked to blood sugar control. Scientists have identified three compounds that strongly inhibited α-glucosidase, an enzyme that plays a central role in breaking down carbohydrates during ...

The preservatives that keep processed foods fresh may also be quietly increasing the risk of type 2 diabetes. Eating more food preservatives, which are commonly added to processed foods and drinks to extend shelf life, has been linked to a higher risk of developing type 2 diabetes. The findings come...

After years of type 2 diabetes, red blood cells may quietly turn against the heart—offering a new clue for spotting danger early. People who live with type 2 diabetes for many years face a steadily increasing risk of cardiovascular disease. New research from Karolinska Institutet, published in the j...

New evidence hints that statins may protect a wider range of people with type 2 diabetes than previously assumed. A major cohort study reports that statin therapy is linked to lower rates of death and serious cardiovascular events in adults living with type 2 diabetes, including people whose predict...

A researcher is planning on investigating potential treatments aimed at the root causes of type 1 diabetes. At the Medical University of South Carolina (MUSC), Leonardo Ferreira, Ph.D., is taking on type 1 diabetes (T1D) with support from a $1 million grant from Breakthrough T1D, the world’s leading...

A global DNA deep dive shows why E. coli infections in diabetic foot wounds can be so stubborn, dangerous, and hard to treat. A new study led by King’s College London, working with the University of Westminster, offers a clearer picture of the E. coli bacteria involved in diabetic foot infections. T...

The experimental drug IC7Fc reduces artery-clogging fats and inflammation in mice, pointing to a potential new strategy for preventing heart disease. Earlier work linked the experimental drug ‘IC7Fc’ to improvements in type 2 diabetes, and new research now points to a possible role in cardiovascular...

Prediabetes can improve without weight loss when fat distribution and metabolic hormones shift in healthier ways. Many people believe that losing weight is the primary way to reduce the risk of developing diabetes. Our new study questions that assumption. For years, doctors have given the same advic...

A large global genetics study shows that many key drivers of Type 2 diabetes operate outside the bloodstream. Scientists are getting a clearer picture of why Type 2 diabetes is so hard to pin down. In a major international project led in part by the University of Massachusetts Amherst and Helmholtz ...

Resistance training improves insulin sensitivity more effectively than endurance exercise in diabetes models. Running is well known for burning calories, but new preclinical research suggests that resistance training may be even more effective when it comes to reducing the risk of obesity and type 2...

Red blood cells may hold the secret to fighting diabetes—by soaking up sugar when oxygen runs low. People who live high in the mountains have long been observed to develop diabetes less often than those at sea level. Scientists have known about this pattern for years, but the biological reason behin...

An “immune system reset” eliminated autoimmune, or Type 1, diabetes in mice in a study conducted at Stanford Medicine. Researchers say the strategy could also have potential for treating other autoimmune diseases and improving outcomes in organ transplantation. In a new study from Stanford Medicine,...

A growing body of research suggests the brain plays a central role in diabetic ketoacidosis, opening the possibility of treating type 1 diabetes in an entirely new way. More than 10 years ago, scientists made an unexpected discovery about a life-threatening complication of type 1 diabetes. They foun...

A clinical trial has found that a widely used and affordable type 2 diabetes medication can lower insulin requirements in people with type 1 diabetes, potentially improving how the condition is managed. For many years, doctors have prescribed metformin, a long-established and widely used medication ...

Why do diabetic wounds refuse to heal? A new scientific review highlights how disruptions in the timing and behavior of immune cells may hold the key to understanding this widespread medical challenge. Chronic diabetic ulcers are among the most serious and costly complications associated with diabet...

Researchers have identified a potential new way to assess metabolic health using saliva instead of blood. High insulin levels in the blood, known as hyperinsulinemia, can reveal metabolic problems long before obvious symptoms appear. It is already recognized as an important warning sign for future h...

Nicotine exposure in fathers may quietly reshape their children’s metabolism, hinting at a hidden link to diabetes risk. New research published today (March 12) in the Journal of the Endocrine Society suggests that nicotine exposure in fathers may influence how their offspring process sugar. In a mo...