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Researchers studying the brain found that women taking oral contraceptives, commonly known as birth control pills, had significantly smaller hypothalamus volume, compared to women not taking the pill, according to a new study presented today at the annual meeting of the Radiological Society of North...
Changes Needed to Prevent Controversial Pharmaceutical Deals Blocking Cheaper Generic Alternatives
(scitechdaily.com)
New research from the University of East Anglia (UEA) recommends changes to the system which sees drug companies strike deals with competitors to stop them from producing cheaper generic alternatives. These ‘pay-for-delay’ deals involve a payment from a branded drug manufacturer to a gen...
Study Shows Hydroxychloroquine’s Harmful Effects on Heart Rhythm – Urges for COVID-19 Use Restrictions
(scitechdaily.com)
The malaria drug hydroxychloroquine, which has been promoted as a potential treatment for COVID-19, is known to have potentially serious effects on heart rhythms. Now, a team of researchers has used an optical mapping system to observe exactly how the drug creates serious disturbances in the electri...
Efficiently Creating “Building Blocks” of Pharmaceuticals to Accelerate Drug Discovery Research
(scitechdaily.com)
Scientists demonstrate new method of producing a specific class of organic compounds, which promises to accelerate drug discovery research for several diseases. Several drugs, including those for depression, schizophrenia, and malaria, would not be if not for a type of organic chemical compound call...
Cannabidiol (CBD) is an increasingly popular wellness trend. The compound, which occurs naturally in cannabis plants, is added to many products that claim to reduce anxiety, alleviate pain and more, without the intoxication of its cousin tetrahydrocannabinol (THC). While CBD products are largely unr...
Pharmaceutical Scientist Warns of Potential Problems With Remdesivir As COVID-19 Treatment
(scitechdaily.com)
University of Cincinnati researcher urges caution using remdesivir to treat COVID-19. While the world has its eyes on vaccines to stop the spread of coronavirus, therapeutics are still necessary to treat hospitalized patients. One of these treatments, remdesivir, is the first and only antiviral agen...
Process Paves a Road to Safe, Ethical, and Fast Drug Manufacturing Envisioning an animal-free drug supply, scientists have — for the first time — reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals. Published on March 2, 2021, in Natu...
Chemical engineers have found a way to load more drug into a tablet, which could then be made smaller and easier to swallow. About 60 percent of drugs on the market have hydrophobic molecules as their active ingredients. These drugs, which are not soluble in water, can be difficult to formulate into...
Harnessing AI to Discover New Drugs: Rewriting the Rulebook for Pharmaceutical Research
(scitechdaily.com)
AI Unlocks New Potential in Natural Drug Discovery Artificial intelligence (AI) is able to recognize the biological activity of natural products in a targeted manner, as researchers at ETH Zurich have demonstrated. Moreover, AI helps to find molecules that have the same effect as a natural substance...
The Virus Trap: Hollow Nano-Objects Made of DNA Could Trap Viruses and Render Them Harmless
(scitechdaily.com)
To date, there are no effective antidotes against most virus infections. An interdisciplinary research team at the Technical University of Munich (TUM) has now developed a new approach: they engulf and neutralize viruses with nano-capsules tailored from genetic material using the DNA origami method....
Existing Drugs Kill SARS-CoV-2 in Cells Since the beginning of the pandemic, researchers worldwide have been looking for ways to treat COVID-19. And while the COVID-19 vaccines represent the best measure to prevent the disease, therapies for those who do get infected remain in short supply. A new gr...
Cannabis Use Could Cause Harmful, Toxic Drug Interactions With Prescription Medications
(scitechdaily.com)
Cannabis compounds, especially CBD and THC metabolites, block key liver and kidney enzymes, increasing risks of drug toxicity or reduced treatment efficacy. Using cannabis alongside other drugs may come with a significant risk of harmful drug-drug interactions, new research by scientists at Washingt...
Not surprisingly, COVID-19 vaccines and antiviral treatments dominated headlines in 2021. But in addition to these breakthroughs, pharmaceutical and biotech companies continued to work on new technologies to treat other diseases. A cover story in Chemical & Engineering News, an independent ...
Improving Symptoms in Patients With Treatment-Resistant Depression Using Pharmacogenetics
(scitechdaily.com)
CAMH-led clinical trial provides further evidence for widespread use of pharmacogenetic testing in prescribing anti-depressants. Pharmacogenetic testing was associated with nearly a two-fold (89 percent) increase in remission rates compared to treatment as usual in a Centre for Addiction and Mental ...
Shocking New Study Finds That 43.5% of Rivers Worldwide Have an Alarming Amount of Pharmaceutical Pollution
(scitechdaily.com)
How Pharmaceutical Ingredients Are Affecting the World’s Rivers Pharmaceutical chemicals in prescription and over-the-counter medications are released into the environment during their manufacturing, usage, and disposal, particularly in surface waters. According to research findings recently publish...
Identification of a Molecular Code Embedded in Protein for Regulating Its Glycosylation Many proteins in nature exist as glycoproteins, which are molecules comprised of protein (polypeptide chain) and glycan (sugar chain). While the protein structure is determined on the basis of its genetic bluepri...