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Researchers link COPB1 gene mutations to a new childhood brain disorder, using tadpoles to confirm the discovery. Scientists have discovered a new genetic disease, which causes some children’s brains to develop abnormally, resulting in delayed intellectual development and often early onset cat...

New Tool Combines Ultrasound, Genetics to Activate Deep Brain Neurons Neurological disorders such as Parkinson’s disease and epilepsy have had some treatment success with deep brain stimulation, but those require surgical device implantation. A multidisciplinary team at Washington University in St. ...

A mutation in four children with polymicrogyria illuminates the role of bioelectricity in early brain development. In polymicrogyria, the cortex of the brain has many irregular, small folds (gyria) and disorganization of its layers. Many affected children have severe developmental delay, intellectua...

An international consortium of leading migraine scientists identified more than 120 regions of the genome that are connected to risk of migraine. The groundbreaking study helps researchers better understand the biological basis of migraine and its subtypes and could speed up the search for a new tre...

Researchers at Mount Sinai have created a computational method that enables the identification of previously unknown genetic causes for primary lymphedema, thoracic aortic aneurysm disease, and congenital deafness. Researchers from the Icahn School of Medicine at Mount Sinai, along with their collea...

A new study in the Journal of Investigative Dermatology uncovers the genes that dictate the direction of hair whorls. The first gene mapping study on human scalp hair whorls not only demonstrates that hair whorl direction has a genetic basis, but also that it is influenced by multiple genes. Four as...

Largest Genetic Study of the Brain Reveals 4,000 Influencing Factors The largest-ever study of the genetics of the brain which analyzed around 36,000 brain scans, has pinpointed over 4,000 genetic factors associated with brain structure. The research, led by the University of Cambridge team, was rec...

A new study of migraine reveals new biological pathways for treatment. A large international study led by deCODE Genetics on the genetics of migraine provides novel insights into the biology of migraine enabling detection of rare variants protecting against migraine, opening an avenue for potential ...

A study by Weill Cornell Medicine shows a genetic variant in the GIP receptor could aid in obesity resistance by enhancing metabolism and insulin release, potentially guiding new treatments. A preclinical study by Weill Cornell Medicine investigators shows that a specific human genetic variant of a ...

New study could improve the ability to make genetic diagnoses and treat neurodevelopmental disorders. Regulation of isoforms — varied versions of RNA and proteins that can be produced from a single gene — is a critical tool in understanding brain development and genetic risk for neuropsychiatric dis...

Researchers have discovered a new cause of why people who lack a specific blood group are genetically predisposed to be overweight or obese. A genetic study led by the University of Exeter identified a link between the SMIM1 gene variant and obesity. This variant, found in individuals without the Ve...

A study on Drosophila reveals that descending neurons (DNs) responsible for behaviors form complex, behavior-specific networks, challenging the notion that individual neurons drive actions independently. This discovery has implications for robotics and the study of motor disorders. A fundamental que...

Scientists employ deep learning to analyze and compare gene regulation across various cell types in human and chicken brains. A recent study published in Science by a Belgian research team investigates how genetic switches that regulate gene activity define brain cell types across different species....

Brain dynamics and cognition share genetic roots. Criticality may guide future brain health research. A recent study published on June 24 in PNAS presents strong evidence that brain criticality—the delicate balance between neural excitation and inhibition—is heavily influenced by genetic factors and...

AI-powered gene maps reveal the hidden control centers driving Alzheimer’s disease — and point to new hope for treatment. A research team led by Min Zhang and Dabao Zhang at the University of California, Irvine’s Joe C. Wen School of Population & Public Health has produced the most comprehensive...

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Abstract: "In Coverage Driven functional verification is a measure of the completeness of a set of tests and the measurable actions is called a coverage task. Functional coverage is defined as functional requirements derived from the user’s requirement and test plan specifications. A coverage dri...

Fossil evidence shows early Homo had primitive, ape-like brains even after leaving Africa, suggesting advanced brain features evolved later than previously assumed. Modern human-like brains evolved comparatively late in the genus Homo and long after the earliest humans first dispersed from Africa, a...

Independent of cholesterol, gene variants raise risk of heart disease, diabetes, high blood pressure. High cholesterol is the most commonly understood cause of atherosclerosis, a hardening of the arteries that raises the risk of heart attack and stroke. But now, scientists at Washington University S...

Largest study of its kind reveals the way relative brain size of mammals changed over the last 150 million years. Scientists from Stony Brook University and the Max Planck Institute of Animal Behavior have pieced together a timeline of how brain and body size evolved in mammals over the last 150 mil...

Salk scientists reveal new insights into neurodegenerative disorders and potential for genetic therapies. Neurons lack the ability to replicate their DNA, so they’re constantly working to repair damage to their genome. Now, a new study by Salk scientists finds that these repairs are not random, but ...

Men with longer CAG repeats in the androgen receptor gene are more likely to suffer severe COVID-19, suggesting a genetic biomarker that could help predict ICU admissions and inform new therapies. Researchers have discovered a novel biomarker to identify male COVID-19 patients most at risk for ICU a...

Scientists at IST Austria discover how a high-risk gene for developing autism spectrum disorder affects brain development. Within the European Union alone, about three million people are affected by an autism spectrum disorder (ASD). Some are only mildly affected and can live independent lives. Othe...

The first evidence of a genetic link explaining why some people who catch COVID-19 don’t become sick has been discovered. A scientific and medical team led by Newcastle University, UK, has demonstrated that the gene, HLA-DRB1*04:01, is found three times as often in people who are asymptomatic....

Gene expression patterns associated with pandemic viral infections provide a map to help define patients’ immune responses, measure disease severity, predict outcomes and test therapies — for current and future pandemics. Researchers at University of California San Diego School of Medicine use...

Researchers linked a spike protein mutation to COVID-19 deaths, a mutation that later appeared in Brazil’s deadly P.1 variant. Viral mutations during the COVID-19 pandemic could cause the SARS-CoV-2 virus to become more dangerous. A new study published in the journal Genetic Epidemiology has ex...

Genetic signals reveal humans first battled coronaviruses over 20,000 years ago—insights that may help shape future pandemic responses. An international team of researchers co-led by the University of Adelaide and the University of Arizona has analyzed the genomes of more than 2,500 modern humans fr...

Genetics toolkit targets less researched Culex mosquitoes, which transmit West Nile virus and avian malaria. Since the onset of the CRISPR genetic editing revolution, scientists have been working to leverage the technology in the development of gene drives that target pathogen-spreading mosquitoes s...